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HPLC-R Acetonitrile High Purity Solvents | Greyhound Chromatography

HPLC-R Acetonitrile High Purity Solvents

         

  • Packed under nitrogen with filtration through 0.2µm
  • Assay (GC, on anhydrous basis) 99.9 - 100%

Biosolve products are manufactured under strict and detailed operating procedures. The manufacturing plants meet the latest environmental and quality ISO standards, serving as the development, production and distribution centers.

From the initial acceptance of selected raw material through process control to the final packed product, all steps are accurately documented. This ensures a high quality of production with lot-to-lot reproducibility and complete traceability for all purposes. Thanks to continual research and development, Biosolve offer one of the finest grade Acetonitrile for HPLC & UHPLC available worldwide: The Supra-gradient grade and the highest brand ULC/MS grade. Manufacturing and recommended expiry dates are clearly stated on the label whenever relevant. Thanks to the strict policy of quality control, Biosolve are an approved vendor to large health organizations, leading pharmaceutical companies and for the chemical and electronic industries.

SOLVENT GRADES

AR Grade - Analytical Reagents generally complying with ACS specifications

Dioxins, Pesti-S, Furans, PCB Analysis Analysed for their suitability in the detection of dioxins, furans & PCBs. ECD and NPD tested for pesticides residue analysis

Extra Dry - Dried solvent for routine synthesis in dry conditions, usually correspond to AR grade solvents which have been subsequently dried and micro-filtered. Display low content of metallic impurities.

GC Headspace – Optimized for accurate analysis of residual solvents. Evaluated against OVI standards to ensure the absence of interfering peaks in the GC chromatogram.

HPLC Carefully prepared, bottled under inert gas and filtered through 0.2µm filters.

HPLC Supra – Quality often guarantees unique specifications, including ultra-low fluorescent impurity levels, outstanding high UV transmission, minimum peak impurities and very low drift in gradient HPLC.

LC-MS – for routing quality work, analysed for low metallic level and good HPLC, UHPLC and MS performance. Filtered through 0.2µm filters.

LV-GC - Suitable for extraction-concentration analysis, analysed for GC-FID, ECD and NPD suitability as well as for PDA performance for the analysis of PAH, GC-Capillary analysis, minute residue analysis, heavy hydrocarbon and mineral oil index analysis. The solvents display high transmittance and low level of fluorescent impurities.

PAH - Highly purified, prepared and finally distilled in all glass systems to ultra-low residual level. These solvents are analyzed by HPLC using UV and Fluorimetric detection in the range of 16 standard polyaromatic hydrocarbons as per EPA 500 and 600 methods Peptide – Hi purity solvents specifically produced for peptide synthesis.

Spectrofluoropure – Guaranteed low fluorescence and/or low UV absorbance levels, also suitable for IR analysis

ULC-MS Highest quality for very demanding work of chromatography, analysed for very high HPLC, UHPLC, SFC and MS performances, coupled with very low amounts of inorganic metallic contaminants. Filtered through 0.1µm filters.

Paragon Scientific Announces UKAS ISO 17025 Accreditation | Greyhound Chromatography

Paragon Scientific has successfully transitioned from ISO Guide 34 to the new standard ISO/IEC 17034:2016, after their recent assessment from the United Kingdom Accreditation Service (UKAS)

                           

 Paragon Scientific 17025 Accreditation PDF Download 

Historically, Paragon Scientific has been accredited to ISO Guide 34 to prove our competency as a Reference Material Producer. A new standard to replace ISO Guide 34 was published in November 2016, ISO 17034, and it was internationally agreed that there will be a 3-year transitionary period to allow organisations accredited to ISO Guide 34 to move to the new standard.

Paragon Scientific  are happy to announce that we have successfully completed the migration as soon as possible, to ensure customers have the confidence we demonstrate technical competence to the latest international requirements.

 Frequently Asked Questions (FAQ):

"Our methods say we must use ISO Guide 34 products. Can we still buy from Paragon?"

Yes,  you  can.  Our  products  still  meet  or  exceed  the  requirements  of ISO Guide 34, and now meet the higher requirements of ISO/IEC 17034:2016.

 "Some of your products still reference ISO Guide 34. Are they still ok to use?"

Yes, they are.  It will take a short time for us to update our calibration certificates, labels and website, but you can be assured that the products are still produced to the high standards you have come to expect from Paragon Scientific.

 "Why should we use a producer accredited to ISO 17034?"

It demonstrates that the Reference Material Producer has been independently assessed and proven to have the technical competence to produce Reference Materials (RMs), including Certified Reference Materials (CRMs) to International recognised standard.

  Benefits of Using an Accredited ISO 17034:

  • Peace of mind. Our accreditation is proof of our technical competence as a Reference Material Producer, independently assessed by UKAS.
  • Internationally recognised credentials. International standards are essential to global cooperation across multiple industries. Our accredited Certified Reference Materials have the right signatories to prove the claims we make and are traceable to international test methods.
  • Quality Assurance. Purchasing accredited Certified Reference Materials provides an opportunity to improve laboratory efficiency, Quality Control and Assurance.
  • Trusted supplier. Not only can customers feel confident about our products, but can trust Paragon Scientific as a supplier for our technical expertise and delivering excellent customer service.

 

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N-nitrosodimethylamine (NDMA) Analytical Reference Standard | Chem Service | Greyhound Chromatography

N-nitrosodimethylamine  (NDMA) Analytical Reference Standard  is available in methanol solution, manufactured by Chem Service Inc and supplied by Greyhound Chromatography

N-Nitrosodimethylamine Solution 100ug/ml in Methanol

Part No: S-12572M1 -1ML  £18.14

 

N-Nitrosodimethylamine Solution 100ug/ml in Methanol

Part No: S-12572M1 - 5ML  £52.97

  

A common drug used to control blood pressure and help prevent heart failure is being recalled in 22 countries because it contains a chemical that poses a potential cancer risk.

Valsartan is off-patent and is used as a component of other generic medicines. Novartis, the company that originally developed the drug, said Sandoz valsartan and valsartan/HCT film-coated tablets are being recalled since they "do not meet our high quality standards." Pharmacies in the UK are advised to recall valsartan batches containing medicines made by Dexcel Pharma Ltd and Accord Healthcare.

 

The recall involves about 2,300 batches that were sent to Germany, Norway, Finland, Sweden, Hungary, the Netherlands, Austria, Ireland, Bulgaria, Italy, Spain, Portugal, Belgium, France, Poland, Croatia, Lithuania, Greece, Canada, Bosnia and Herzegovina, Bahrain and Malta.
Novartis spokesman Eric Althoff said that products sold in the United States are not affected by this recall. Sandy Walsh, a spokeswoman for the US Food and Drug Administration said the agency is aware of the situation and "has no comment at this time," adding that the FDA is "committed to informing the public in a timely manner when the agency identifies safety issues. Generally, the agency does not comment on third-party announcements, but evaluates them as part of the body of evidence to further our understanding about a particular issue and assist in our mission to protect public health." 
The problem was discovered during tests of batches of valsartan's active pharmaceutical ingredient (API), as those from an external supplier contained an impurity. The European Medicines Agency reviewed medicines from the supplier, Zhejiang Huahai Pharmaceuticals in Linhai, China. The agency said the impurity is "a result of a change in the manufacturing process."
 
The impurity is N-Nitrosodimethylamine (NDMA), an organic chemical that is in a family of potent carcinogens. The chemical has been used to make liquid rocket fuel, softeners and lubricants, among other products. It can also be unintentionally produced through certain chemical reactions and is a byproduct from some pesticide manufacturing, the making of rubber tires or fish processing.
 
Animal studies have shown that NDMA can be toxic and cause tumors in the liver, kidney and respiratory tract. It can also be potentially harmful to humans in certain quantities. Exposure to high levels can cause liver damage and is a probable human carcinogen, according to the US Department of Health and Human Services.
 
"The amounts of NDMA found in Valsartan API are much lower than the cumulative endogenous production and usual external exposure of NDMA,"Althoff wrote in an email. "There is no certainty as to how much this contaminant may potentially increase cancer risk in humans. Thus, the amount of NDMA found in the Valsartan API would not represent a significantly increased risk to the patients taking of Sandoz Valsartan and Sandoz Valsartan HCT Film coated tablets."
The European Medicines Agency and EU regulators are working to determine what impact this might have on patients and whether other drugs will be affected. The external supplier is used by other pharmaceutical companies, as well, according to Novartis' statement, but the spokesman said it could not comment on those companies. The company says that no other Sandoz or Novartis products, even those that may contain valsartan, are affected by the recall.
 
"We continue to undertake an urgent review of all these products that may pose a low risk to public health," said Dr. Sam Atkinson, director of the UKMedicines and Healthcare products Regulatory Agency's Inspection, Enforcement and Standards Division.
Novartis said that although the amount of the NDMA in the drug isn't considered a "significantly increased risk to the patients," patients should talk with their doctors to discuss treatment options as a precaution.
 
Patients shouldn't stop taking their medicine, but the Medicines and Healthcare products Regulatory Agency said it is vital that they get in touch with their doctors "as soon as possible." Alternative medicines that are unaffected by the recall are available.
 
"They key with this is, patients should not stop taking their medication abruptly, that definitely can be harmful," said Dr. Mary Ann Bauman a representative for the American Heart Association. "You don't want to jump to any conclusions on your own about this medication, or any medication for that matter. Definitely talk with your doctor first."

For over 35 years Greyhound Chromatography has been supplying high quality Chromatography consumables to laboratories around the world. Greyhound’s extensive range covers all areas of Environmental, Petrochemical, Food, Forensics, Chemical and Pharmaceutical analysis. Backed by a highly experienced technical services team, Greyhound is the preferred source amongst today’s analysts.


Greyhound Chromatography is pleased to supply Chem Service Certified Reference Standards to Research and Analysis laboratories worldwide.

 

The benefits of using Chem Service Certified Reference Standards:

 

High Quality: High purity chemicals for use as certified reference materials

Cost Effective: Products packaged in small quantities to minimize expenses
Wide Selection: 1,200 pesticide and metabolite reference standards (including banned and discontinued items)
Certification backed with experience: 50 years of experience. ISO 9001:2008 : ISO/IEC 17025:2005 certification :
ISO Guide 34:2009 For Organic Reference Material

 

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