PFAS analysis in fish tissue by HPLC-MS/MS 

Development of extraction and cleanup approachesfor PFASsanalysis in fish tissue by HPLC-MS/MS technique

A V Sorokin, V V Ovcharenko, K A Turbabina, A I Kozhushkevich, A M Kalantaenko, A A Komarov

The Russian State Center for Quality and Standardization of Veterinary Drugs and Feed (VGNKI), Moscow, Russia, 123022

 

Abstract. The history of PFASs emergence and current status in the context of the Stockholm Convention on POPs, their environmental distribution and toxicity are discussed. Various approaches to PFASs analysis in fish tissues are discussed. An original method of sample preparation is described, which allows quantitative PFASs determination at 0.2 – 100 ppb levels.

1.   Introduction

Perfluorinated compounds (PFASs), classified according to the recommended terminology [1], are a large family of technogenic contaminants. The family consist of different compound classes, such as carboxylates, sulfonates, sulfonamides, alcohols and etc., of which carboxylates and sulfonates are most often analysed in laboratories. PFASs started to emerge into the environment in the late 40s as by-products of Teflon development by DuPont. Teflon was approved by FDA for kitchenware coating in 1962, and Zonyl was approved for food packaging in 1967. At present, PFASs are used in textile industry, paper production, as components in various resins, foams, etc. Accordingly, perfluorooctanoic acid (PFOA) (Fig. 1) was first detected in the blood samples of factory personnel in 1978, and in the ground water in 1984. Due to toxicity concerns, some companies stopped producing 8-carbon PFAS since 2000.

 

 

PFASs are stable contaminants capable of bioaccumulation, they are detected in animal tissues. At present, the worldwide production of PFASs has been reduced due to information about their potential health risks, including risks of cancer promotion. According to the European Union data on PFAS in food collected in 2006 – 2012, perfluoroalkanesulfonates (PFSAs) and perfluoroalkylcarboxylicacids (PFCAs) are the most widespread food contaminants. PFSAs were mostly found in fish, meat, drinking water and fruits. The highest levels were detected in liver samples.

High levels of PFCAs and PFSAs were found in marine mammals feeding on fish in such industrially developed areas as the Baltic Sea, Mediterranean, the Great Lakes, and along the South East Asia coast, but also in such remote areas as Alaska and the Antarctic (Table 1).

 

 Most common approaches to PFASs extraction and cleanup involve methanol, acetonitrile, and their mixtures with acidic or alkaline modifications followed by SPE cleanup on commercial sorbents.  Here we report on the determination of perfluorinated carboxylates and sulfonates in medium-fat fish tissues using an alternative method of lipids removal described below.

 

DOWNLOAD THE FULL PAPER HERE  PDF

Acknowledgement to:

A V Sorokin, V V Ovcharenko, K A Turbabina, A I Kozhushkevich, A M Kalantaenko, A A Komarov

The Russian State Center for Quality and Standardization of Veterinary Drugs and Feed (VGNKI), Moscow, Russia, 123022

For permission to publish this paper. 

 

You May Also be Interested in

New Branched Perfluoroalkyl Reference Standards

     

It is well documented that many environmental samples contain both branched and linear isomers of perfluoroalkyl carboxylic acids and perfluoroalkanesulfonate salts.  In response to customer requests for quantitative reference standards for these compounds, wellington Laboratories has synthesized additional branched perfluoroalkyl compounds (P3MHpA, P4MOA, and NaP3MHpS) to complement their currently available selection of standards.  A typical commercial sample of perfluorooctanesulfonic acid (PFOS) contains 5% and 11% of NaP3MHpS and NaP6MHpS respectively.  Similarly, technical mixtures of perfluorooctanoic acid (PFOA) contain approximately 3% of P3MHpA.  It is hoped that the continued introduction of certified branched perfluoroalkyl reference standrds will aid researchers in the analysis of these compounds in environmental and biological samples.

Wellington Reporter May 2019

3,6-Dibromo-9H-carbazole Certified Reference Standard

                

Halogenated carbazoles have recently been recognised as emerging environmental contaminants. Although there exact source has not been determined, both modern and historic sources (LED manufacturing and halogenated indigo dyes respectively) have been suggested. Since certain halogenated carbazole congeners can be lost during acid silica clean-up, it is very important that reference standards be used to monitor recoveries when processing samples.

Wellington Laboratories are the primary source of Standards for branched isomers, linear perfluoroalkyl carboxylic acids, perfluoroalkane sulfonates, Certified Reference Standards, EPA Method 23, EPA Method 513, EPA Method 1613, EPA Method 1668, EPA Method EPA Method 8280, EPA Method 8290, European Method EN-1948 and World Health/EPA Standards, C13 and Native Dioxins, Furans, PCBs and Brominated Diphenyl Ethers, Brominated Dioxins and Furans, Methylated PCDDs and PCDFs, Fluorinated Compounds.

3,6-Dibromo-9H-carbazole Certified Reference Standards - Buy Online HERE

 

Halogenated Carbazole Certified Reference Standards from Wellington Laboratories - more info HERE

For over 30 years Greyhound Chromatography has been supplying high quality Chromatography consumables to laboratories around the world. Greyhound’s extensive range covers all areas of Environmental, Petrochemical, Food, Forensics, Chemical and Pharmaceutical analysis. Backed by a highly experienced technical services team, Greyhound is the preferred source amongst today’s analysts.

Greyhound Chromatography is pleased to supply Wellington Laboratories Certified Reference Standards and Materials to Research and Analysis laboratories worldwide.

3-Chloro-9H-carbazole Certified Reference Standard 

            

 

Wellington Laboratories are the primary source of Standards for EPA Method 23, EPA Method 513, EPA Method 1613, EPA Method 1668, EPA Method 8280, EPA Method 8290, European Method EN-1948 and World Health/EPA Standards, C13 and Native Dioxins, Furans, PCBs and Brominated Diphenyl Ethers, Brominated Dioxins and Furans, Methylated PCDDs and PCDFs, Fluorinated Compounds and more.

CCZ-3 3-Chloro-9H-carbazole  Buy online HERE

For over 30 years Greyhound Chromatography has been supplying high quality Chromatography consumables to laboratories around the world. Greyhound’s extensive range covers all areas of Environmental, Petrochemical, Food, Forensics, Chemical and Pharmaceutical analysis. Backed by a highly experienced technical services team, Greyhound is the preferred source amongst today’s analysts.

Greyhound Chromatography is pleased to supply Chem Service Certified Reference Standards to Research and Analysis laboratories worldwide.

1,3,6-Tribromo-9H-carbazole Halogenated Carbazole Certified Reference Standard

                

Wellington Laboratories are the primary source of Standards for branched isomers, linear perfluoroalkyl carboxylic acids, perfluoroalkane sulfonates, Certified Reference Standards, EPA Method 23, EPA Method 513, EPA Method 1613, EPA Method 1668, EPA Method EPA Method 8280, EPA Method 8290, European Method EN-1948 and World Health/EPA Standards, C13 and Native Dioxins, Furans, PCBs and Brominated Diphenyl Ethers, Brominated Dioxins and Furans, Methylated PCDDs and PCDFs, Fluorinated Compounds.

For over 30 years Greyhound Chromatography has been supplying high quality Chromatography consumables to laboratories around the world. Greyhound’s extensive range covers all areas of Environmental, Petrochemical, Food, Forensics, Chemical and Pharmaceutical analysis. Backed by a highly experienced technical services team, Greyhound is the preferred source amongst today’s analysts.

 

1,3,6-Tribromo-9H-carbazole Halogenated Carbazole Certified Reference Standards - Buy Online HERE

Greyhound Chromatography is pleased to supply Wellington Laboratories Certified Reference Standards and Materials to Research and Analysis laboratories worldwide.

1,3,6,8-Tetrachloro-9H-[13C12]carbazole Certified Reference Standard

       

 

Wellington Laboratories are the primary source of Standards for EPA Methods 23, 513, 1613, 1668, 8280, 8290, European Method EN-1948 and World Health/EPA Standards, C13 and Native Dioxins, Furans, PCBs and Brominated Diphenyl Ethers, Brominated Dioxins and Furans, Methylated PCDDs and PCDFs, Fluorinated Compounds and more.

Wellington Laboratories has been committed to providing high quality reference standards and exceptional customer service since its inception in 1980. An acute awareness of trends in the environmental community and a dedication to research and development has allowed us to synthesize a variety of emerging contaminants over the years. A few examples of The Science Behind Wellington are provided below for your review.

Halogenated carbazoles have recently been recognized as emerging environmental contaminants, but
research groups have been reporting their existence in environmental samples since 1984. There may be
multiple sources of these pollutants, but it has recently been suggested that they were produced as by-
products during the synthesis of halogenated indigo dyes. Since unsubstituted carbazoles are known to be
lost during acid silica clean-up, it is very important that reference standards be used when processing
samples.

In order to aid researchers in the detection of halogenated carbazoles in environmental samples, 
Wellington has produced certified reference standards of selected halogenated carbazoles

CCZ-3
CCZ-36
CCZ-1368
CCZ-2367
BCZ-3
BCZ-27
BCZ-136
BCZ-1368
1-B-36-CCZ
18-B-36-CCZ

as well as two certified reference standards of mass-labelled chlorinated carbazoles (MCCZ-36 and MCCZ-1368).

For over 40 years Greyhound Chromatography has been supplying high quality Chromatography consumables to laboratories around the world. Greyhound’s extensive range covers all areas of Environmental, Petrochemical, Food, Forensics, Chemical and Pharmaceutical analysis. Backed by a highly experienced technical services team, Greyhound is the preferred source amongst today’s analysts.

Greyhound Chromatography is pleased to supply Wellington Laboratories' Certifieded Reference Standards and materials to Research and Analysis laboratories worldwide.

Native 3,6-Dichloro-9H-[13C12]carbazole
Native & Mass-Labelled Halogenated Carbazoles

 

           

 

Halogenated carbazoles have recently been recognised as emerging environmental contaminants. Although there exact source has not been determined, both modern and historic sources (LED manufacturing and halogenated indigo dyes respectively) have been suggested. Since certain halogenated carbazole congeners can be lost during acid silica clean-up, it is very important that reference standards be used to monitor recoveries when processing samples.

Wellington Laboratories are the primary source of Standards for EPA Methods 23, 513, 1613, 1668, 8280, 8290, European Method EN-1948 and World Health/EPA Standards, C13 and Native Dioxins, Furans, PCBs and Brominated Diphenyl Ethers, Brominated Dioxins and Furans, Methylated PCDDs and PCDFs, Fluorinated Compounds and more.

MCCZ-36: 3,6-Dichloro-9H-[13C12]carbazole

Other Native and Mass-Labelled Halogenated Carbazoles available from Wellington Laboratories:

 

MCCZ-1368: 1,3,6,8-Tetrachloro-9H-[13C12]carbazole

CCZ-3: 3-Chloro-9H-carbazole
CCZ-36: 3,6-Dichloro-9H-carbazole
CCZ-1368: 1,3,6,8-Tetrachloro-9H-carbazole
CCZ-2367: 2,3,6,7-Tetrachloro-9H-carbazole

BCZ-3: 3-Bromo-9H-carbazole
BCZ-27: 2,7-Dibromo-9H-carbazole
BCZ-136: 1,3,6-Tribromo-9H-carbazole
BCZ-1368: 1,3,6,8-Tetrabromo-9H-carbazole

1-B-36-CCZ: 1-Bromo-3,6-Dichloro-9H-carbazole
18-B-36-CCZ: 1,8-Dibromo-3,6-Dichloro-9H-carbazol

 

Halogenated carbazoles have recently been detected in soil and water samples, but their environmental effects and fate are unknown. Eighty-four soil samples obtained from a site with no recorded history of pollution were used to assess the persistence and dioxin-like toxicity of carbazole and chlorocarbazoles in soil under controlled conditions for 15 months. Soil samples were divided into two temperature conditions, 15 and 20 °C, both under fluctuating soil moisture conditions comprising 19 and 44 drying-rewetting cycles, respectively. This was characterized by natural water loss by evaporation and rewetting to -15 kPa. Accelerated solvent extraction (ASE) and cleanup were performed after incubation. Identification and quantification were done using high-resolution gas chromatogram/mass spectrometer (HRGC/MS), while dioxin-like toxicity was determined by ethoxyresorufin-O-deethylase (EROD) induction in H4IIA rat hepatoma cells assay and multidimensional quantitative structure-activity relationships (mQSAR) modelling. Carbazole, 3-chlorocarbazole and 3,6-dichlorocarbazole were detected including trichlorocarbazole not previously reported in soils. Carbazole and 3-chlorocarbazole showed significant dissipation at 15 °C but not at 20 °C incubating conditions indicating that low temperature could be suitable for dissipation of carbazole and chlorocarbazoles. 3,6-Dichlorocarbazole was resistant at both conditions. Trichlorocarbazole however exhibited a tendency to increase in concentration with time. 3-Chlorocarbazole, 3,6-dibromocarbazole and selected soil extracts exhibited EROD activity. Dioxin-like toxicity did not decrease significantly with time, whereas the sum chlorocarbazole toxic equivalence concentrations (∑TEQ) did not contribute significantly to the soil assay dioxin-like toxicity equivalent concentrations (TCDD-EQ). Carbazole and chlorocarbazoles are persistent with the latter also toxic in natural conditions.

Affiliation
Courtesy of: German Research Center for Environmental Health, Molecular EXposomics (MEX), Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

For over 30 years Greyhound Chromatography has been supplying high quality Chromatography consumables to laboratories around the world. Greyhound’s extensive range covers all areas of Environmental, Petrochemical, Food, Forensics, Chemical and Pharmaceutical analysis. Backed by a highly experienced technical services team, Greyhound is the preferred source amongst today’s analysts.

Greyhound Chromatography is pleased to supply Wellington Laboratories' Certified Reference Standards and Materials  to Research and Analysis laboratories worldwide.

  Download the current Wellington Laboratories Catalogue HERE

1,3,6,8-Tetrabromo-9H-carbazole Certified Reference Standard

 

         

Halogenated carbazoles have recently been recognised as emerging environmental contaminants. Although there exact source has not been determined, both modern and historic sources (LED manufacturing and halogenated indigo dyes respectively) have been suggested. Since certain halogenated carbazole congeners can be lost during acid silica clean-up, it is very important that reference standards be used to monitor recoveries when processing samples.

 1,3,6,8-Tetrabromo-9H-carbazole Certified Reference Standard - Buy online HERE

 For over 38 years Greyhound Chromatography has been supplying high quality Chromatography consumables to laboratories around the world. Greyhound’s extensive range covers all areas of Environmental, Petrochemical, Food, Forensics, Chemical and Pharmaceutical analysis. Backed by a highly experienced technical services team, Greyhound is the preferred source amongst today’s analysts.

 Greyhound Chromatography is pleased to supply Wellington Laboratories Certified Reference Standards and Materials to Research and Analysis laboratories worldwide.

 You May also be Interested in

 Agilent Certified, pre-assembled screw top vial pack, 2 mL, clear vials, PTFE/red rubber septa, blue caps

   

 Genuine Agilent Part: 5182-0553

 Description

Agilent Certified, pre-assembled screw top vial pack, 2 mL, clear vials, PTFE/red rubber septa, blue caps, 100/pk

   Agilent Flash lamp for G1321A

  Genuine Agilent Part: 2140-0600

 Description

Agilent Flash lamp for G1321A fluorescence detector

 Agilent Snap top vial, 2 mL, amber with write-on spot

 

                                  

 Genuine Agilent Part: 5182-0545

 Description

 Agilent Snap top vial, 2 mL, amber with write-on spot, 100/pk

   View the full range of Greyhound Syringe Filters 

 Regenerated Cellulose Syringe Filters

 Q-Fil Certified Syringe Filters

 Q-Fil Certified Syringe Filters set the new Quality standard for today’s laboratory syringe filters Manufactured from the highest quality medical grade high density polypropylene, Q-Fil Certified Syringe Filters provide excellent chemical compatibility with acids, alcohols, bases, ethers, glycols, ketones and oils, with maximum operating temperatures of 135°C.

 Every colour-coded filter is printed with the individual batch number, details of the membrane material and its pore size, on the outside rim of the filter, making them unique for traceability, GLPs and validation purposes.

 BUY HERE

 

 Why filter your samples for HPLC?

 • To protect the HPLC column, the column inlet frits and capillary columns against blockage (plugging) caused by particulate matter in the sample

• To protect injection valves from damage caused by scratching and wear of the valves internal components, caused by harmful particulate matter in the unfiltered sample, thereby reducing instrument downtime.

   About our Quality Control procedures

 • Every batch of filters is tested by an independent laboratory to ISO 17025 quality procedures

 • Every individual Q-Fil Certified Syringe Filter is visually inspected to ensure it meets our manufacturing and quality control specifications

• Samples of all our syringe filters and their respective raw technical data are stored for a period of 5 years from the date of manufacture for future reference
• Each batch of filters is tested prior to release for
- External Dimensions
- Bubble Point
- Burst Pressure
- Filter Integrity
- Water Flow Rate
- UV Extractables and compliance with all technical procedures

   Why use Greyhound Q-Fil Certified Syringe Filters?

 • Q-Fil Certified Syringe Filters are manufactured in compliance with ISO 9001:2000 quality procedures

 • Every box is supplied with a Certificate of Analysis and Conformance to guarantee its batch to batch quality and performance

• The unique encapsulating process developed for these filters, forces the sample to pass only through the membrane, thus avoiding the possibility of leaks or contamination
• Available in the most popular sizes, porosities and membrane types
• Excellent resistance to all routinely used HPLC solvents
• Filter housings are manufactured from high density medical grade polypropylene
• Extremely low level of extractables for highly sensitive work
• Luer connections fully comply with ISO 594-1
• Filters are available with standard and ‘SlimTip’ sized outlets

   Selecting the right Q-Fil Certified Syringe Filter

 • Choose the size of filter based on the volume of sample to be filtered

 • Choose the filters porosity based on the size of the potential particulates in the sample. It is important to be aware that the finer the porosity of the membrane the greater the pressure will be required to pass the sample through the filter. A sample containing large quantities of particulates is best filtered using a filter with a built-in glass fibre pre-filter

• Choose the type of membrane based on the solvent being filtered.

 

Filter Sizes

 All our filters have female Luer Lock inlets and are available in three diameters -

 25mm Diameter

Designed for large sample volumes or solvent filtration
Wide cross sectional area 3.55cm2
Maximum filtration volume >10ml
Maximum operating pressure 550 Kpa

 13mm Diameter

Suitable for most applications
Filtration area of 0.95cm2
Maximum filtration volume 1 to 10ml Maximum operating pressure 750 Kpa Now available with ‘SlimTip’ (ST) outlet

 4mm Diameter

Suitable for most applications Ideal for small samples <1ml Pore sizes of 0.20µm and 0.45µm
SlimTip Filters (ST)
13mm diameter syringe filters are now available with the new ‘SlimTip’ outlet for direct filling of microvials.

   Pore Sizes

 Q-Fil Certified Syringe Filters are available in 0.20µm and 0.45µm pore sizes. The 0.20µm filters remove the smallest particulates whilst the 0.45µm filters are designed to remove particulates which would be detrimental to most analytical columns.

 Pre-filters (page 6) have a glass microfibre membrane which is chemically inert and resists most solvents. Q-Fil glass microfibre pre-filters are recommended for removing large particulates from the sample and are ideal for dissolution tests.

 Glass microfibre membranes are also available mounted before the microporous filter membrane in the polypropylene housing. The glass pre-filter removes the larger particulates and prevents premature clogging of the filter.

  

CONTACT US   

Tel:        +44 (0) 151 649 4000   

Web:     www.greyhoundchrom.com   

Email:   marketing@greyhoundchrom.com   

FOLLOW US   

       

YOU MAY ALSO BE INTERESTED IN OUR NEWSLETTER   

SIGN UP HERE   

   

CATALOGUE DOWNLOADS   

      

        

              

                

 

 

Native Perfluoroalkylsulfonates (PFASs) Supplied by Greyhound Chromatography Manufactured by Wellington Laboratories.

New Products: NATIVE/MASS-LABELLED HALOGENATED CARBAZOLES

3,6-Dichloro-9H-carbazole Certified Reference Standard | Greyhound Chromatography

1,3,6-Tribromo-9H-carbazole Halogenated Carbazole Certified Reference Standard | Greyhound Chromatography

2,2’,3,3’,4,5,5’,6,6’-Nonabromo-4’-chlorodiphenyl ether (4PC-BDE-208) Certified Analytical Reference Standard Greyhound Chromatography

N-[3-(perfluoro-1-hexanesulfonamido)propan-1-yl]-N,N,N-trimethylammonium - 1.2 ml x 50ug/ml in methanol  - Cas # 38850-51-0

Latest Environmental News

Denmark just became the first country to ban PFAS from food packaging

Denmark will be the first country to ban PFAS Chemicals, which have been linked to cancer, elevated cholesterol and decreased fertility, from food packaging, starting next year.

PFAS substances, sometimes called "forever chemicals" because they don't break down in the environment, are used to repel grease and water in packaging for fatty and moist foods such as burgers and cakes.

 

What are PFAS chemicals, and what are they doing to our health?

"I do not want to accept the risk of harmful fluorinated substances (PFAS) migrating from the packaging and into our food. These substances represent such a health problem that we can no longer wait for the EU," Denmark's Food Minister Mogens Jensen said in a statement Monday.

PFAS chemicals are a family of potentially thousands of synthetic chemicals that are extremely persistent in the environment and in our bodies. PFAS is short for perfluoroalky and polyfluoroalkyl substances, and includes chemicals known as PFOS, PFOA and GenX.

They are all identified by signature elemental bonds of fluorine and carbon, which are extremely strong and what make it so difficult for these chemicals to disintegrate in the environment or in our bodies.

Under Denmark's new regulation, baking paper and microwave popcorn bags, for example, will be required to be manufactured without any PFAS.

"We congratulate Denmark on leading the way for healthier food and hope this will encourage similar action across the EU, the US and worldwide," said Arlene Blum of the Green Science Policy Institute and the Department of Chemistry at University of California, Berkeley.

 

FDA confirms PFAS chemicals are in the US food supply

"Given the potential for harm, we must ask if the convenience of water and grease resistance is worth risking our health," Blum said.

PFAS chemicals have been manufactured since the 1940s and can be found in Teflon nonstick products, stains and water repellants, paints, cleaning products, food packaging and firefighting foams.

These chemicals can easily migrate into the air, dust, food, soil and water. People can also be exposed to them through food packaging and industrial exposure.

A growing body of science has found that there are potential adverse health impacts associated with PFAS exposure, including liver damage, thyroid disease, decreased fertility, high cholesterol, obesity, hormone suppression and cancer.

 

In a statement, the Danish Veterinary and Food Administration said that the substances were very difficult to break down in the environment, and some of them accumulate in humans and animals.

The ban covers the use of PFAS compounds in food contact materials of cardboard and paper. The Danish government said it would continue to be possible to use recycled paper and paper for food packaging, but said PFAS compounds must be separated from the food with a barrier which ensures that they don't migrate into the food.

PFOS and PFOA are the two most-studied PFAS chemicals and have been identified as contaminants of emerging concern by the US Environmental Protection Agency.

PFOS was voluntarily phased out of production in the United States by 3M, the main manufacturer, starting in 2000. In 2006, PFOA began to be phased out as well. PFOA and PFOS are no longer manufactured or imported in the United States, but similar "replacement chemicals for PFOA and PFOS such as GenX, may be just as persistent," Susan M. Pinney, a professor in the Department of Environmental Health at the University of Cincinnati.

The European Food Safety Agency said it is reassessing the risks PFAS pose to human health and will report on its findings in the near future.

 

Wellington Laboratories offer a wide range of Certified Reference Standards for Testing and Analysis of Perfluorinated Compounds.

 Perfluorinated Compounds (PFCs)

 

Per- and Polyfluoroalkyl Substances (PFAS) are an emerging class of environmental contaminants. Their unique properties create a host of analytical challenges that require the use of native and mass-labelled standards for the generation of accurate data.

 

The most notable PFAS include PFOS (perfluorooctanesulfonate) and PFOA (perfluorooctanoic acid) and Wellington currently offers multiple mass-labelled standards for these compounds to meet your analytical needs. In fact, Wellington offers a large selection of native and mass-labelled per- and poly-fluorinated compounds, including:

•                   Perfluoroalkylcarboxylic Acids (PFCAs)
•                   Perfluoroalkylsulfonates (PFASs)
•                   Perfluorooctanesulfonamides (FOSAs)
•                   Perfluorooctanesulfonamidoethanols (FOSEs)
•                   Perfluorooctanesulfonamidoacetic acids (FOSAAs)
•                   Telomer Alcohols (FTOHs)
•                   Telomer Acids (FTAs)
•                   Telomer Sulfonates (FTSs)
•                   Perfluoroalkylphosphonic acids (PFAPAs)
•                   Perfluoroalkylphosphinic acids (PFPi’s)
•                   …and more

These solutions can be found on pages 141 – 159 of Wellington Laboratories’ current catalogue.

Progress and Developments from Wellington Laboratories in 2019/2020

•          New PFAS Mixtures and Solutions

About Wellington Laboratories

For more than 40 years Wellington Laboratories Inc. has been internationally recognised as a trusted source of high quality reference standard solutions for use in environmental/analytical testing and toxicological research. Wellington Laboratories offers an extensive inventory of individual certified reference standards and solution mixtures of native and mass-labelled halogenated organic compounds including polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, halogenated flame retardants and perfluorinated compounds. Wellington Laboratories also offer a variety of calibration sets and support solutions designed to be used for common regulatory methods or modified in-house methods.

Wellington’s Reference Standards are used mainly in Environmental/analytical testing and toxicological research. Wellington offers an extensive inventory of individual certified reference standards and solution mixtures of native and mass-labelled halogenated organic compounds including polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, halogenated flame retardants and perfluoronated compounds. Wellington also offer a variety of calibration sets and support solutions designed to be used for common regulatory methods of modified in-house methods.

Wellington Laboratories are committed to the distribution of quality products as well as the maintenance of excellent customer service. In fact, in order to provide your customers with the best possible service, Wellington have three ISO certifications (ISO 9001:2008, ISO/IEC 17025:2005, and ISO Guide 34:2009) which cover all aspects of planning, production, testing, distribution, and post-distribution service. These certifications allow Wellington Laboratories to monitor and maintain the highest level of quality and service and also allow their customers to satisfy the requirements of their own ISO certifications.

Wellington’s ISO/IEC 17025:2005 accreditation has been certified by the Canadian Association for Laboratory Accreditation Inc. (CALA) the scope is available for review on the CALA Directory of Accredited Laboratories (http://www.cala.ca).

Similarly, Wellington’s ISO Guide 34:2009 accreditation has been certified by ANSI-ASQ National Accreditation Board (ANAB), the certificate and scope are available on their website (http://anab.org/).

We are able to supply hard copies of any of the ISO certificates for yourself and your customers.

Request a C of A.

 

Full Range of Wellington Laboratories' Products

 

 

CONTACT US   

Tel:        +44 (0) 151 649 4000   

Web:     www.greyhoundchrom.com   

Email:   marketing@greyhoundchrom.com   

FOLLOW US   

       

YOU MAY ALSO BE INTERESTED IN OUR NEWSLETTER   

SIGN UP HERE   

   

CATALOGUE DOWNLOADS   

      

        

              

                

About the Author

Susan Massie, Sales & Marketing Director, Greyhound Chromatography and Allied Chemicals Email: sue@greyhoundchrom.com

Susan Massie is the Sales & Marketing Director for Greyhound Chromatography and Allied Chemicals, affectionately known as 'Greyhound' in our scientific community. Greyhound was founded by Susan's husband Paul Massie  over 40 years ago, Susan hasn't been in the business for all of that time but has been involved with Greyhound for over 17 years. Greyhound continues to grow, expanding into new markets and taking on the challenges of our ever changing environment. It's heartwarming to witness the world waking up to the fact that we are damaging our planet on a daily basis. Every action we take has a direct effect on our planet and the world we leave behind for future generations. Susan is passionate about climate change and is happy to work in an industry that can have a direct effect on reducing the impact of our actions on the environment. All of the team at Greyhound take our responsibilities very seriously, the products that we supply are used by the world's leading scientists and chemists as they endeavour to monitor and repair the environment. All is not lost, if we all take responsibility for our actions, from reducing our waste and reusing or recycling our material collateral we can make a difference. The internet is full of useful advice and guidance, Susan is proud to contribute to that wealth of knowledge whenever she can.

Greyhound prides itself on personal service which provides prompt, efficient, cost-effective, safe delivery of all products. Greyhound provides technical advice and distribution of Certified Reference Standards and Materials, Laboratory Consumables, Solvents and Reagents across all scientific disciplines. Greyhound Chromatography offers over 1 Million products from its UK warehouse. The team at Greyhound are proud to support the work of the world's leading scientists and chemists as they challenge the abuse of our planet and try to make a difference to the world we leave behind for our ancestors.

You can view Susan's Linked In Profile here https://www.linkedin.com/in/susan-massie-79ab4121/

N-(3-dimethylaminopropan-1-yl)perfluoro-1-hexanesulfonamide

Cas # 50598-28-2 Certified reference Standards

Latest Environmental News

Denmark just became the first country to ban PFAS from food packaging

Denmark will be the first country to ban PFAS Chemicals, which have been linked to cancer, elevated cholesterol and decreased fertility, from food packaging, starting next year.

PFAS substances, sometimes called "forever chemicals" because they don't break down in the environment, are used to repel grease and water in packaging for fatty and moist foods such as burgers and cakes.

 

What are PFAS chemicals, and what are they doing to our health?

"I do not want to accept the risk of harmful fluorinated substances (PFAS) migrating from the packaging and into our food. These substances represent such a health problem that we can no longer wait for the EU," Denmark's Food Minister Mogens Jensen said in a statement Monday.

PFAS chemicals are a family of potentially thousands of synthetic chemicals that are extremely persistent in the environment and in our bodies. PFAS is short for perfluoroalky and polyfluoroalkyl substances, and includes chemicals known as PFOS, PFOA and GenX.

They are all identified by signature elemental bonds of fluorine and carbon, which are extremely strong and what make it so difficult for these chemicals to disintegrate in the environment or in our bodies.

Under Denmark's new regulation, baking paper and microwave popcorn bags, for example, will be required to be manufactured without any PFAS.

"We congratulate Denmark on leading the way for healthier food and hope this will encourage similar action across the EU, the US and worldwide," said Arlene Blum of the Green Science Policy Institute and the Department of Chemistry at University of California, Berkeley.

 

FDA confirms PFAS chemicals are in the US food supply

"Given the potential for harm, we must ask if the convenience of water and grease resistance is worth risking our health," Blum said.

PFAS chemicals have been manufactured since the 1940s and can be found in Teflon nonstick products, stains and water repellants, paints, cleaning products, food packaging and firefighting foams.

These chemicals can easily migrate into the air, dust, food, soil and water. People can also be exposed to them through food packaging and industrial exposure.

A growing body of science has found that there are potential adverse health impacts associated with PFAS exposure, including liver damage, thyroid disease, decreased fertility, high cholesterol, obesity, hormone suppression and cancer.

 

In a statement, the Danish Veterinary and Food Administration said that the substances were very difficult to break down in the environment, and some of them accumulate in humans and animals.

The ban covers the use of PFAS compounds in food contact materials of cardboard and paper. The Danish government said it would continue to be possible to use recycled paper and paper for food packaging, but said PFAS compounds must be separated from the food with a barrier which ensures that they don't migrate into the food.

PFOS and PFOA are the two most-studied PFAS chemicals and have been identified as contaminants of emerging concern by the US Environmental Protection Agency.

PFOS was voluntarily phased out of production in the United States by 3M, the main manufacturer, starting in 2000. In 2006, PFOA began to be phased out as well. PFOA and PFOS are no longer manufactured or imported in the United States, but similar "replacement chemicals for PFOA and PFOS such as GenX, may be just as persistent," Susan M. Pinney, a professor in the Department of Environmental Health at the University of Cincinnati.

The European Food Safety Agency said it is reassessing the risks PFAS pose to human health and will report on its findings in the near future.

 

Wellington Laboratories offer a wide range of Certified Reference Standards for Testing and Analysis of Perfluorinated Compounds.

 Perfluorinated Compounds (PFCs) 

Per- and Polyfluoroalkyl Substances (PFAS) are an emerging class of environmental contaminants. Their unique properties create a host of analytical challenges that require the use of native and mass-labelled standards for the generation of accurate data.

 

The most notable PFAS include PFOS (perfluorooctanesulfonate) and PFOA (perfluorooctanoic acid) and Wellington currently offers multiple mass-labelled standards for these compounds to meet your analytical needs. In fact, Wellington offers a large selection of native and mass-labelled per- and poly-fluorinated compounds, including:

•                   Perfluoroalkylcarboxylic Acids (PFCAs)
•                   Perfluoroalkylsulfonates (PFASs)
•                   Perfluorooctanesulfonamides (FOSAs)
•                   Perfluorooctanesulfonamidoethanols (FOSEs)
•                   Perfluorooctanesulfonamidoacetic acids (FOSAAs)
•                   Telomer Alcohols (FTOHs)
•                   Telomer Acids (FTAs)
•                   Telomer Sulfonates (FTSs)
•                   Perfluoroalkylphosphonic acids (PFAPAs)
•                   Perfluoroalkylphosphinic acids (PFPi’s)
•                   …and more

These solutions can be found on pages 141 – 159 of Wellington Laboratories’ current catalogue.

Progress and Developments from Wellington Laboratories in 2019/2020

•          New PFAS Mixtures and Solutions

 

About Wellington Laboratories

For more than 40 years Wellington Laboratories Inc. has been internationally recognised as a trusted source of high quality reference standard solutions for use in environmental/analytical testing and toxicological research. Wellington Laboratories offers an extensive inventory of individual certified reference standards and solution mixtures of native and mass-labelled halogenated organic compounds including polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, halogenated flame retardants and perfluorinated compounds. Wellington Laboratories also offer a variety of calibration sets and support solutions designed to be used for common regulatory methods or modified in-house methods.

Wellington’s Reference Standards are used mainly in Environmental/analytical testing and toxicological research. Wellington offers an extensive inventory of individual certified reference standards and solution mixtures of native and mass-labelled halogenated organic compounds including polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, halogenated flame retardants and perfluoronated compounds. Wellington also offer a variety of calibration sets and support solutions designed to be used for common regulatory methods of modified in-house methods.

Wellington Laboratories are committed to the distribution of quality products as well as the maintenance of excellent customer service. In fact, in order to provide your customers with the best possible service, Wellington have three ISO certifications (ISO 9001:2008, ISO/IEC 17025:2005, and ISO Guide 34:2009) which cover all aspects of planning, production, testing, distribution, and post-distribution service. These certifications allow Wellington Laboratories to monitor and maintain the highest level of quality and service and also allow their customers to satisfy the requirements of their own ISO certifications.

Wellington’s ISO/IEC 17025:2005 accreditation has been certified by the Canadian Association for Laboratory Accreditation Inc. (CALA) the scope is available for review on the CALA Directory of Accredited Laboratories (http://www.cala.ca).

Similarly, Wellington’s ISO Guide 34:2009 accreditation has been certified by ANSI-ASQ National Accreditation Board (ANAB), the certificate and scope are available on their website (http://anab.org/).

We are able to supply hard copies of any of the ISO certificates for yourself and your customers.

Request a C of A.

 

Full Range of Wellington Laboratories' Products

 About the Author

Susan Massie, Sales & Marketing Director, Greyhound Chromatography and Allied Chemicals Email: sue@greyhoundchrom.com

Susan Massie is the Sales Marketing Director for Greyhound Chromatography and Allied Chemicals, affectionately known as 'Greyhound' in our scientific community. Greyhound was founded by Susan's husband Paul Massie over 40 years ago, Susan hasn't been in the business for all of that time but has been involved with Greyhound for over 17 years. Greyhound continues to grow, expanding into new markets and taking on the challenges of our ever changing environment. It's heartwarming to witness the world waking up to the fact that we are damaging our planet on a daily basis. Every action we take has a direct effect on our planet and the world we leave behind for future generations. Susan is passionate about climate change and is happy to work in an industry that can have a direct effect on reducing the impact of our actions on the environment. All of the team at Greyhound take our responsibilities very seriously, the products that we supply are used by the world's leading scientists and chemists as they endeavour to monitor and repair the environment. All is not lost, if we all take responsibility for our actions, from reducing our waste and reusing or recycling our material collateral we can make a difference. The internet is full of useful advice and guidance, Susan is proud to contribute to that wealth of knowledge whenever she can.

Greyhound prides itself on personal service which provides prompt, efficient, cost-effective, safe delivery of all products. Greyhound provides technical advice and distribution of Certified Reference Standards and Materials, Laboratory Consumables, Solvents and Reagents across all scientific disciplines. Greyhound Chromatography offers over 1 Million products from its UK warehouse. The team at Greyhound are proud to support the work of the world's leading scientists and chemists as they challenge the abuse of our planet and try to make a difference to the world we leave behind for our ancestors.

You can view Susan's Linked In Profile here https://www.linkedin.com/in/susan-massie-79ab4121/

CONTACT US   

Tel:        +44 (0) 151 649 4000   

Web:     www.greyhoundchrom.com   

Email:   marketing@greyhoundchrom.com   

FOLLOW US   

       

YOU MAY ALSO BE INTERESTED IN OUR NEWSLETTER   

SIGN UP HERE   

   

CATALOGUE DOWNLOADS   

      

        

              

                

N-(carboxymethyl)-N,N-dimethyl-N-[3-(1H,1H,2H,2H-perfluoro-1-octanesulfonamido)propan-1-yl]ammonium (6:2FTAB)

Latest Environmental News

Denmark just became the first country to ban PFAS from food packaging

Denmark will be the first country to ban PFAS Chemicals, which have been linked to cancer, elevated cholesterol and decreased fertility, from food packaging, starting next year.

PFAS substances, sometimes called "forever chemicals" because they don't break down in the environment, are used to repel grease and water in packaging for fatty and moist foods such as burgers and cakes.

 

What are PFAS chemicals, and what are they doing to our health?

"I do not want to accept the risk of harmful fluorinated substances (PFAS) migrating from the packaging and into our food. These substances represent such a health problem that we can no longer wait for the EU," Denmark's Food Minister Mogens Jensen said in a statement Monday.

PFAS chemicals are a family of potentially thousands of synthetic chemicals that are extremely persistent in the environment and in our bodies. PFAS is short for perfluoroalky and polyfluoroalkyl substances, and includes chemicals known as PFOS, PFOA and GenX.

They are all identified by signature elemental bonds of fluorine and carbon, which are extremely strong and what make it so difficult for these chemicals to disintegrate in the environment or in our bodies.

Under Denmark's new regulation, baking paper and microwave popcorn bags, for example, will be required to be manufactured without any PFAS.

"We congratulate Denmark on leading the way for healthier food and hope this will encourage similar action across the EU, the US and worldwide," said Arlene Blum of the Green Science Policy Institute and the Department of Chemistry at University of California, Berkeley.

 

FDA confirms PFAS chemicals are in the US food supply

"Given the potential for harm, we must ask if the convenience of water and grease resistance is worth risking our health," Blum said.

PFAS chemicals have been manufactured since the 1940s and can be found in Teflon nonstick products, stains and water repellants, paints, cleaning products, food packaging and firefighting foams.

These chemicals can easily migrate into the air, dust, food, soil and water. People can also be exposed to them through food packaging and industrial exposure.

A growing body of science has found that there are potential adverse health impacts associated with PFAS exposure, including liver damage, thyroid disease, decreased fertility, high cholesterol, obesity, hormone suppression and cancer.

 

In a statement, the Danish Veterinary and Food Administration said that the substances were very difficult to break down in the environment, and some of them accumulate in humans and animals.

The ban covers the use of PFAS compounds in food contact materials of cardboard and paper. The Danish government said it would continue to be possible to use recycled paper and paper for food packaging, but said PFAS compounds must be separated from the food with a barrier which ensures that they don't migrate into the food.

PFOS and PFOA are the two most-studied PFAS chemicals and have been identified as contaminants of emerging concern by the US Environmental Protection Agency.

PFOS was voluntarily phased out of production in the United States by 3M, the main manufacturer, starting in 2000. In 2006, PFOA began to be phased out as well. PFOA and PFOS are no longer manufactured or imported in the United States, but similar "replacement chemicals for PFOA and PFOS such as GenX, may be just as persistent," Susan M. Pinney, a professor in the Department of Environmental Health at the University of Cincinnati.

The European Food Safety Agency said it is reassessing the risks PFAS pose to human health and will report on its findings in the near future.

 

Wellington Laboratories offer a wide range of Certified Reference Standards for Testing and Analysis of Perfluorinated Compounds.

 Perfluorinated Compounds (PFCs) 

Per- and Polyfluoroalkyl Substances (PFAS) are an emerging class of environmental contaminants. Their unique properties create a host of analytical challenges that require the use of native and mass-labelled standards for the generation of accurate data.

 

The most notable PFAS include PFOS (perfluorooctanesulfonate) and PFOA (perfluorooctanoic acid) and Wellington currently offers multiple mass-labelled standards for these compounds to meet your analytical needs. In fact, Wellington offers a large selection of native and mass-labelled per- and poly-fluorinated compounds, including:

•                   Perfluoroalkylcarboxylic Acids (PFCAs)
•                   Perfluoroalkylsulfonates (PFASs)
•                   Perfluorooctanesulfonamides (FOSAs)
•                   Perfluorooctanesulfonamidoethanols (FOSEs)
•                   Perfluorooctanesulfonamidoacetic acids (FOSAAs)
•                   Telomer Alcohols (FTOHs)
•                   Telomer Acids (FTAs)
•                   Telomer Sulfonates (FTSs)
•                   Perfluoroalkylphosphonic acids (PFAPAs)
•                   Perfluoroalkylphosphinic acids (PFPi’s)
•                   …and more

These solutions can be found in the new Wellington Laboratories' catalogue. 

Progress and Developments from Wellington Laboratories in 2019/2020

•          New PFAS Mixtures and Solutions

 

About Wellington Laboratories

For over 40 years Wellington Laboratories Inc. has been internationally recognised as a trusted source of high quality reference standard solutions for use in environmental/analytical testing and toxicological research. Wellington Laboratories offers an extensive inventory of individual certified reference standards and solution mixtures of native and mass-labelled halogenated organic compounds including polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, halogenated flame retardants and perfluorinated compounds. Wellington Laboratories also offer a variety of calibration sets and support solutions designed to be used for common regulatory methods or modified in-house methods.

Wellington’s Reference Standards are used mainly in Environmental/analytical testing and toxicological research. Wellington offers an extensive inventory of individual certified reference standards and solution mixtures of native and mass-labelled halogenated organic compounds including polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, halogenated flame retardants and perfluoronated compounds. Wellington also offer a variety of calibration sets and support solutions designed to be used for common regulatory methods of modified in-house methods.

Wellington Laboratories are committed to the distribution of quality products as well as the maintenance of excellent customer service. In fact, in order to provide your customers with the best possible service, Wellington have three ISO certifications (ISO 9001:2008, ISO/IEC 17025:2005, and ISO Guide 34:2009) which cover all aspects of planning, production, testing, distribution, and post-distribution service. These certifications allow Wellington Laboratories to monitor and maintain the highest level of quality and service and also allow their customers to satisfy the requirements of their own ISO certifications.

Wellington’s ISO/IEC 17025:2005 accreditation has been certified by the Canadian Association for Laboratory Accreditation Inc. (CALA) the scope is available for review on the CALA Directory of Accredited Laboratories (http://www.cala.ca).

Similarly, Wellington’s ISO Guide 34:2009 accreditation has been certified by ANSI-ASQ National Accreditation Board (ANAB), the certificate and scope are available on their website (http://anab.org/).

We are able to supply hard copies of any of the ISO certificates for yourself and your customers.

Request a C of A.

 

Full Range of Wellington Laboratories' Products

CONTACT US   

Tel:        +44 (0) 151 649 4000   

Web:     www.greyhoundchrom.com   

Email:   marketing@greyhoundchrom.com   

FOLLOW US   

       

YOU MAY ALSO BE INTERESTED IN OUR NEWSLETTER   

SIGN UP HERE   

   

CATALOGUE DOWNLOADS   

      

        

              

                

 

About the Author

Susan Massie, Sales & Marketing Director, Greyhound Chromatography and Allied Chemicals Email: sue@greyhoundchrom.com

Susan Massie is the Sales & Marketing Director for Greyhound Chromatography and Allied Chemicals, affectionately known as 'Greyhound' in our scientific community. Greyhound was founded by Susan's husband Paul Massie over 40 years ago, Susan hasn't been in the business for all of that time but has been involved with Greyhound for over 17 years. Greyhound continues to grow, expanding into new markets and taking on the challenges of our ever changing environment. It's heartwarming to witness the world waking up to the fact that we are damaging our planet on a daily basis. Every action we take has a direct effect on our planet and the world we leave behind for future generations. Susan is passionate about climate change and is happy to work in an industry that can have a direct effect on reducing the impact of our actions on the environment. All of the team at Greyhound take our responsibilities very seriously, the products that we supply are used by the world's leading scientists and chemists as they endeavour to monitor and repair the environment. All is not lost, if we all take responsibility for our actions, from reducing our waste and reusing or recycling our material collateral we can make a difference. The internet is full of useful advice and guidance, Susan is proud to contribute to that wealth of knowledge whenever she can.

Greyhound prides itself on personal service which provides prompt, efficient, cost-effective, safe delivery of all products. Greyhound provides technical advice and distribution of Certified Reference Standards and Materials, Laboratory Consumables, Solvents and Reagents across all scientific disciplines. Greyhound Chromatography offers over 1 Million products from its UK warehouse. The team at Greyhound are proud to support the work of the world's leading scientists and chemists as they challenge the abuse of our planet and try to make a difference to the world we leave behind for our ancestors.

You can view Susan's Linked In Profile here https://www.linkedin.com/in/susan-massie-79ab4121/