Understand the chemistry behind Albendazole
Albendazole is an organic compound and benzimidazole drug best known for treating parasite issues. It is a broad-spectrum anthelmintic and can be used on both humans and animals for a variety of issues, including tapeworm, nematodes and hydatoses. Albendazole standards can be useful for testing the drug for use or research.
Although albendazole is a popular drug and is used all across the world to treat humans and animals, many people in the chemistry industry may not even be aware of the details behind this chemical compound, which has been listed on the World Health Organization's list of important medications.
Albendazole's discovery
As Stanford University explained, albendazole is far from the first benzimidazole tested, but it proved to be one of the most successful. Smith Kline & French Animal Health marketed the chemical compound for animal use in the late 1970s. But further testing revealed that this drug was not only effective on animals, but superior to many other benzimidazoles available for humans because it metabolized into more anthelminthics and was not toxic.
In the late 1980s, albendazole was approved for human use and has been prescribed around the world. It has continued to be used not only for its effectiveness against intestinal parasites, but also because it is relatively inexpensive and popular internationally.
Usage details
Albendazole's chemical name is C12H15N3O2S and it has a molecular weight of 265.3314. Other commercial names for the chemical compound are Albenza, Eskazole, Valbazen, Zentel, Albendazol, Proftril, Bilutac and Albendazolum, the United States' National Center for Biotechnology Information explained.
Albendazole works as an inhibitor, inducer and substrate, with the human gut absorbing less than 1 percent of the chemical and the rest being released as waste. The primary purpose of the drug is to kill parasites through impairing their intake of glucose in larval and adult stages. Additionally, albendazole sulfoxide becomes albendazole sulfone when metabolized, which can also be effective against parasites, Stanford underscored.
Experimental guidelines
With an experimental melting point between 208 and 210 C, there are a number of uses for albendazole in the lab. The National Institutes of Health and the U.S. Department of Health and Human Services published a large amount of information on this chemical compound and guidelines for testing and use in a lab setting. For example, the pharmaceutical preparation of albendazole as a tablet requires "liquid chromatography detection at 254 nm and comparison to standards."
Albendazole has already been a beneficial chemical for many people around the world, but there are a number of other experimental uses for the compound that may further improve how it can help humanity.
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About the Author
Susan Massie, Sales & Marketing Director, Greyhound Chromatography and Allied Chemicals Email: sue@greyhoundchrom.com
Susan Massie is the Sales & Marketing Director for Greyhound Chromatography and Allied Chemicals, affectionately known as 'Greyhound' in our scientific community. Greyhound was founded by Susan's husband Paul Massie more than 40 years ago, Susan hasn't been in the business for all of that time but has been involved with Greyhound for over 17 years. Greyhound continues to grow, expanding into new markets and taking on the challenges of our ever changing environment. It's heartwarming to witness the world waking up to the fact that we are damaging our planet on a daily basis. Every action we take has a direct effect on our planet and the world we leave behind for future generations. Susan is passionate about climate change and is happy to work in an industry that can have a direct effect on reducing the impact of our actions on the environment. All of the team at Greyhound take our responsibilities very seriously, the products that we supply are used by the world's leading scientists and chemists as they endeavour to monitor and repair the environment. All is not lost, if we all take responsibility for our actions, from reducing our waste and reusing or recycling our material collateral we can make a difference. The internet is full of useful advice and guidance, Susan is proud to contribute to that wealth of knowledge whenever she can.
Greyhound prides itself on personal service which provides prompt, efficient, cost-effective, safe delivery of all products. Greyhound provides technical advice and distribution of Certified Reference Standards and Materials, Laboratory Consumables, Solvents and Reagents across all scientific disciplines. Greyhound Chromatography offers over 1 Million products from its UK warehouse. The team at Greyhound are proud to support the work of the world's leading scientists and chemists as they challenge the abuse of our planet and try to make a difference to the world we leave behind for our ancestors.
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